A double-blind study by Phylos and People Science found that THCV increases energy and motivation without causing the increased appetite or tiredness usually associated with THC. THCV shows potential for therapeutic applications, including as a CB1 receptor antagonist to avoid THC's side effects and in dermatological treatments, highlighting its unique benefits beyond energy boosting.
In the realm of cannabinoids, the spotlight often falls on THC. However, lurking within the depths of cannabis is a less known gem: THCV. Recent findings from a double-blind clinical study conducted by Phylos, a company specializing in cannabis genetics, and People Science, a cannabis research firm, have illuminated the potential of THCV, a minor cannabinoid naturally present in certain cannabis strains.
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Dubbed ‘diet weed’ due to its lack of appetite stimulation, THCV has garnered attention for its unique properties. As revealed by the study, THCV has energizing effects without the tiredness and cravings typical of THC. Among the 78 participants who received THCV-infused candies, a significant number reported feeling more energetic and more engaged in daily activities than participants who received a placebo.
In this study, participants were given either placebo candies, candies containing only delta-9 THC, or THCV-dominant candies. While the THC-only candies induced hunger in 50% of participants, the THCV group did not show a statistically significant increase in appetite.
Furthermore, tiredness, a common side effect of THC, was reported three times more frequently in the THC-only group than in the THCV group. Both THC-only and THCV candies had positive effects on activity, motivation, and overall well-being, but THCV stood out for its unique energizing properties.
Although the study has not yet been published in a peer-reviewed journal, Alisha Holloway, Chief Scientific Officer at Phylos, weighed in on its significance by stating, “This study marks a turning point for the cannabis industry by enabling an understanding of the effect of THCV in combination with THC. The study allows us to leverage our exceptional plants to develop targeted cannabis-based products, and to explore new territories to understand the efficacy of natural cannabinoids.”
Beyond its energizing effects, THCV shows promise in therapeutic applications. While researchers have not delved into the mechanisms underlying THCV’s unique effects in this study, previous research suggests its potential as a CB1 receptor antagonist, offering a pathway to circumvent common side effects associated with THC, such as increased appetite. Moreover, studies have suggested THCV’s role in dermatological treatments, hinting at a broader spectrum of therapeutic benefits.
The quest to unlock the potential of cannabis continues to spur scientific research. Recent revelations from Washington State University have shed light on how cannabis activates specific neurons in the brain, thus elucidating the subtleties of cannabis-induced appetite stimulation.
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(Featured image by Daniel Norin via Unsplash)
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