New findings suggest a shared genetic basis for cannabis use and mental disorders like schizophrenia and bipolar disorder. The findings, which confirm earlier research conducted in 2018, dispel a common myth about the link between cannabis and mental disorders. Understanding these genetic predispositions could lead to better prevention, intervention, and individualized treatment plans.
A genetics study conducted by the University of Oslo, published in the renowned journal Lancet Psychiatry, reports a shared genetic basis for cannabis use and mental disorders, including schizophrenia and bipolar disorder.
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Such a discovery may suggest that a certain portion of the population has an increased risk of both cannabis use and the development of mental disorders, which is linked to their genetic predisposition.
Over the years, we have witnessed many debates about the association between cannabis use and mental disorders. In the latest research, it has been found that the frequency of cannabis use is high among patients suffering from mental disorders such as schizophrenia and bipolar disorder, but cannabis is not a factor influencing the development of these disorders. Rather, it now appears to be their genetic predisposition rather than a causal link with cannabis.
Genetics plays a significant role in determining an individual’s susceptibility to developing mental disorders or the likelihood of cannabis use. Some genetic variants associated with them are also linked to psychiatric disorders.
A new study conducted at the University of Oslo, published in Lancet Psychiatry, has shown that there is a genetic basis for both cannabis use and psychiatric conditions such as schizophrenia and bipolar disorder.
The study shows that the majority of shared genetic variants increase the risk of both cannabis use and the development of schizophrenia or bipolar disorder. However, there are certain genetic variants with opposing effects that increase the risk of cannabis use while decreasing the risk of developing these two psychiatric disorders, suggesting a complex relationship.
“These findings are significant because they demonstrate that the intricate connections between cannabis use and these disorders may not be solely caused by cannabis use itself but may also be driven by shared genetic predispositions,” says researcher Nadine Parker.
A study published in Nature Neuroscience in 2018 revealed a similar association. Scientists identified approximately 35 genes that may indicate a person’s increased susceptibility to “lifetime cannabis use.”
The new results have several important clinical implications:
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