Science & Medical

Patients report a reduction in symptoms after using CBD for seizures

Despite Epidiolex approval, researchers aren't sure why prescription CBD can control severe seizures. According to a recent study where 224 patients were tested, the frequency of their seizures was reduced by almost 50% on average, compared to 27% in the placebo group. Doctors and researchers still do not know how CBD works in its entirety. Thiele presented the findings at a meeting in Baltimore.

A preliminary study suggests that using CBD for seizures may help control difficult-to-treat conditions caused by rare genetic disorders.

The study included 224 patients with complex tuberous sclerosis (CTS), a genetic condition that affects about one in 6,000 people, according to the U.S. National Institutes of Health.

It causes noncancerous tumors to appear throughout the body, and in 90% of cases, seizures that are resistant to standard drugs.

The Hemp.im application organizes what’s happening in the cannabis world to help you learn more about the stories that matter to you.

Stay informed with the latest hemp news and get the important information in one application.

CBD for seizures tested through Epidolex

The researchers wanted to know if these patients could respond to Epidiolex, a liquid drug that contains purified cannabidiol (CBD).

In 2018, the U.S. Food and Drug Administration (FDA) approved Epidiolex for two other seizure disorders: Dravet syndrome and Lennox-Gastaut syndrome. This made it the first approved drug to contain an ingredient derived from cannabis plants.

CBD is one of the hundreds of compounds found in cannabis. It is different from THC, the compound that causes the famous sensation of “getting high.” CBD is found in cannabis but is more abundant in hemp.

How CBD for seizures reduces symptoms

Despite the approval of Epidiolex, researchers aren’t sure why prescription CBD for seizures can help control symptoms and severe attacks.

“All standard anticonvulsants work through similar mechanisms, and CBD apparently resolves them differently,” said Dr. Elizabeth Thiele, who led the study. “CBD works through a novel mechanism, but we don’t know exactly what it is.”

Thiele is also the Director of Pediatric Epilepsy at Massachusetts General Hospital in Boston.

With funding from the manufacturer of the Epidiolex, GW Research Ltd., his team tested the drug on 224 CTS patients at medical centers in six countries. Half of the patients were under 11 and typically had tried four anticonvulsants before they had to stop for several reasons.

“Because they didn’t work, for example, or because of side effects,” Thiele said.

Epidiolex is the first drug approved by the FDA to contain an ingredient derived from cannabis plants. (Source)

CBD can help to reduce seizures by 50%

Researchers randomly assigned patients to take 25 milligrams (mg) or 50 mg of Epidiolex each day or a placebo. This was in addition to any standard anticonvulsants they were taking. Over 16 weeks, patients using either dose of CBD for seizures were more likely to see improvement.

The frequency of their seizures was reduced by almost 50%, on average, compared to 27% in the placebo group.

Those taking the highest dose of CBD for seizures were also more likely to have at least a 50% reduction in the frequency of their seizures. It occurred in 40% compared with 22% of those receiving the placebo.

Epidolex found to have some benefits

Thiele presented the findings on Dec. 16, at the American Epilepsy Society (AES) annual meeting in Baltimore. Studies presented at meetings are generally considered preliminary until they are published in a peer-reviewed journal.

“Based on 16-week results, Epidiolex has a “modest” benefit over placebo,” said Dr. William Gaillard, president-elect of AES.

__

(Featured image by Stefan Rodriguez via Unsplash)

DISCLAIMER: This article was written by a third party contributor and does not reflect the opinion of Hemp.im, its management, staff or its associates. Please review our disclaimer for more information.

This article may include forward-looking statements. These forward-looking statements generally are identified by the words “believe,” “project,” “estimate,” “become,” “plan,” “will,” and similar expressions. These forward-looking statements involve known and unknown risks as well as uncertainties, including those discussed in the following cautionary statements and elsewhere in this article and on this site. Although the Company may believe that its expectations are based on reasonable assumptions, the actual results that the Company may achieve may differ materially from any forward-looking statements, which reflect the opinions of the management of the Company only as of the date hereof. Additionally, please make sure to read these important disclosures.

First published in Debate, a third-party contributor translated and adapted the article from the original. In case of discrepancy, the original will prevail.

Although we made reasonable efforts to provide accurate translations, some parts may be incorrect. Hemp.im assumes no responsibility for errors, omissions or ambiguities in the translations provided on this website. Any person or entity relying on translated content does so at their own risk. Hemp.im is not responsible for losses caused by such reliance on the accuracy or reliability of translated information. If you wish to report an error or inaccuracy in the translation, we encourage you to contact us.

Eva Wesley

Eva Wesley is an experienced journalist, market trader, and financial executive. Driven by excellence and a passion to connect with people, she takes pride in writing think pieces that help people decide what to do with their investments. A blockchain enthusiast, she also engages in cryptocurrency trading. Her latest travels have also opened her eyes to other exciting markets, such as aerospace, cannabis, healthcare, and telcos.

Recent Posts

Women Represent 61% of Home Cannabis Growers in the U.S.

A survey found that women comprise 61% of home cannabis growers, marking a diversion from…

21 hours ago

Denmark Proposes Making Its Medical Cannabis Program Permanent

Denmark plans to make its pilot medical cannabis program permanent following its success in treating…

2 days ago

Polish Lawmakers Petition Donald Tusk for Cannabis Decriminalization

Polish lawmakers have submitted a non-binding petition to Prime Minister Donald Tusk, urging cannabis decriminalization…

1 week ago

The UK Medical Cannabis Market: Growth, Diversification, and Opportunities

The UK medical cannabis market has rapidly grown since legalization in 2018, with private actors…

1 week ago

Alcohol & Cannabis: 60% of Cannabis Users Say It Helps Them Drink Less

A new study involving over 23,000 participants in New Zealand found that 60% of people…

1 week ago

French Interior and Justice Ministers Announce Measures to Combat Organized Crime

The French Ministers of the Interior and Justice announced a comprehensive plan to tackle organized…

2 weeks ago